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Skin absorption is a route by which substances can enter the body through the skin. Along with inhalation, ingestion and injection, dermal absorption is a route of exposure for toxic substances and route of administration for medication. Absorption of substances through the skin depends on a number of factors, the most important of which are concentration, duration of contact, *solubility of medication *, and physical condition of the skin and part of the body exposed. Skin (percutaneous, dermal) absorption is a term that describes the transport of chemicals from the outer surface of the skin both into the skin and into the systemic circulation. Skin absorption relates to the degree of exposure to and possible effect of a substance which may enter the body through the skin. Human skin comes into contact with many agents intentionally and unintentionally. Skin absorption can occur from occupational, environmental, or consumer skin exposure to chemicals, cosmetics, or pharmaceutical products. Some chemicals can be absorbed in enough quantity to cause detrimental systemic effects. Skin disease (dermatitis) is considered one of the most common occupational diseases.〔(Workplace Safety & Health Topics: Skin Exposures & Effects ). ''CDC''. Retrieved April 17, 2014.〕 In order to assess if a chemical can be a risk of either causing dermatitis or other more systemeic effects and how that risk may be reduced one must know the extent to which it is absorbed, thus dermal exposure is a key aspect of human health risk assessment. == Factors influencing absorption == Along with inhalation, ingestion and injection, dermal absorption is a route of exposure for bioactive substances including medications.〔Eaton, DL and Klaassen Curtis D. Principles of Toxicology. in Cassarett & Doull's Toxicology, ''The Basic Science of Poisons''. 5th edition. 1996. McGraw-Hill.〕 Absorption of substances through the skin depends on a number of factors: * Concentration * Molecular Weight of the molecule〔http://www.ncbi.nlm.nih.gov/pubmed/10839713〕 * Duration of contact * Solubility of medication * Physical condition of the skin * Part of the body exposed including the amount of hair on the skin. In general the rate of absorption of chemicals through skin follows the following scheme from fastest to slowest: Scrotal > Forehead > Armpit≥ Scalp > Back = Abdomen > Palm = under surface of the foot.〔Baynes, RE and Hodgson E. Absorption and Distribution of Toxicants. in Chapter 6 of A Textbook of modern toxicology. 3rd edition. 2004, John Wiley & Sons, Inc.〕 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Absorption (skin)」の詳細全文を読む スポンサード リンク
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